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Hollow iron oxide nanoparticles as multidrug resistant drug delivery and imaging vehicles

ISSN号：1998-0124
期刊名称：Nano Research
时间：2013.1
页码：1-9
分类：TQ110[化学工程—无机化工] O482.532[理学—固体物理;理学—物理]
作者机构：[1]Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA, [2]Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China, [3]Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361005, China
相关基金：Acknowledgements This research was supported in part by the National Basic Research Program of China （973 Program, Nos. 2013CB733802 and 2010CB934602）; the National Science Foundation of China （NSFC, Nos. 81101101, 81201086, 81201129, 81201190, 51273165, 51172005 and 81028009）; the Chinese Academy of Sciences Professorship for Senior International Scientists （No. 2011T2J06）; and the Intramural Research Program （IRP） of the National Institute of Biomedical Imaging and Bioengineering （NIBIB）, National Institutes of Health （NIH）. R. X. is partially supported by the China Scholarship Council.
相关项目：离子诱导的单相碳化铁化学合成及其磁学与催化性能研究

作者： Sun, Xiaolian|Liu, Gang|Hou, Yanglong|Chen, Xiaoyuan|

关键词：核磁共振成像, 铁纳米粒子, 化疗药物, 多药耐药, 氧化, 车辆, 交付, 空心, drug resistance,hollow nanoparticles,doxorubicin,magnetic resonanceimaging （MRI）,drug delivery

中文摘要：

磁性的 nanoparticles 对很多个癌症房间被用作药交货车辆。大多数这些 theranostic 明确的表达使用了为两磁性的回声成像(MRI ) 和癌症治疗作为 nano 搬运人明确的表达与 chemotherapeutics 装载的稳固的氧化铁 nanoparticles (SIONP ) 。在这研究，我们使用了 dopamine-plus-human 浆液白朊(HSA ) 方法在 nano 搬运人的空多孔的结构以内修改空氧化铁 nanoparticles (HIONP ) 和 encapsuated doxorubicin (纪录影片) 。新交货系统能用一样的涂层策略比一样的核心尺寸的稳固的氧化铁 nanoparticles 装载更多的药。HIONPs 纪录影片明确的表达也有 pH 依赖的药版本行为。与免费纪录影片相比， HIONPs 纪录影片有效地是更多由 multidrug 的 uptaken 抵抗 OVCAR8-ADR 房间并且因而在杀死药的更多的有势力抵抗癌症房间。MRI 幽灵和房间研究也证明 HIONPs 纪录影片能减少当充当药交货车辆时， T 2 MRI 信号紧张和罐头被用作一个 MRI 对比代理人。第一次， chemo 药运输的双申请和用 HIONPs 纪录影片明确的表达的先生成像对纪录影片敏感、纪录影片抵抗的癌症房间被完成。

英文摘要：

Magnetic nanopartides have been used as drug delivery vehicles against a number of cancer cells. Most of these theranostic formulations have used solid iron oxide nanoparticles （SIONPs） loaded with chemotherapeutics as nano-carrier formulation for both magnetic resonance imaging （MRI） and cancer therapy. In this study, we applied the dopamine-plus-human serum albumin （HSA） method to modify hollow iron oxide nanoparticles （HIONPs） and encapsuated doxorubicin （DOX） within the hollow porous structure of the nano-carrier. The new delivery system can load more drug than solid iron oxide nanoparticles of the same core size using the same coating strategy. The HIONPs-DOX formulation also has a pH-dependent drug release behaviour. Compared with free DOX, the HIONPs-DOX were more effectively uptaken by the multidrug resistant OVCAR8- ADR cells and consequently more potent in killing drug resistant cancer cells. MRI phantom and cell studies also showed that the HIONPs-DOX can decrease the T2 MRI signal intensity and can be used as a MR/contrast agent while acting as a drug delivery vehicle. For the first time, the dual application of chemo drug transport and MR imaging using the HIONPs-DOX formulation was achieved against both DOX-sensitive and DOX-resistant cancer cells.