中文摘要：

血管纹和螺旋韧带位于耳蜗中阶外侧壁，其中血管纹的血-迷路屏障（blood-labyrinth barrier,BLB）是高度分化的毛细血管网，用于调控耳蜗血液和细胞间液的物质交换。此屏障保护内耳不接触来自血液的有毒物质，并且选择性的透过离子、液体及营养物质至耳蜗。血-迷路屏障对维持耳蜗内稳态有重要的作用。血迷路屏障结构上包括血管纹微血管内皮细胞（endothelial cells,ECs）、周细胞（pericytes,PCs）、血管周围巨噬细胞样黑色素细胞（perivascular resident macrophage-like melanocytes,PVM/Ms）、基膜（basement membrance,BM）、复杂的紧密连接和黏合连接。ECs、PCs和PVM/Ms间的作用，类似于细胞间信号传导，对控制血管渗透性及为听功能提供适宜的环境起着至关重要的作用。在遗传缺陷、炎症、声损伤以及衰老的病理条件下，血-迷路屏障各组份间正常的相互作用遭到破坏，进而导致其通透性增加，引发听力障碍。

英文摘要：

The stria vascularis and spiral ligament are located in the lateral wall of the cochlea.The blood-labyrinthbarrier(BLB)of the stria vascularis is a well-differentiated capillary network that regulates exchanges between theblood and interstitial fluid in the cochlea.This barrier protects the inner ear from toxic substances that are produced byblood and selectively allows fluids,ions and nutrients into the cochlea.The BLB plays an important role in maintainingcochlear homeostasis.The BLB includes vascular endothelial cells(ECs),basement membrane(BM),elaborated tightand adherens junctions,pericytes(PCs),and perivascular resident macrophage-like melanocytes(PVM/Ms).Interactionsbetween ECs,PVM/Ms and PCs,similar to intercellular signaling,play a vital role in controlling vascular permeabilityand providing a suitable environment for hearing function.Breakdown of normal interactions between componentsof the BLB participates in genetic defects,inflammation,acoustic injury and aging.