中文摘要：

银屑病是皮肤科常见病、多发病，病因不清。目前认为，银屑病的发病机制主要是由T细胞介导的以角质形成细胞（KC）为靶点的免疫应答反应、辅助性T细胞22（Th22）是一种近几年新发现的T细胞亚群，其功能主要通过白细胞介素22（IL-22）来实现的目前，对Th22细胞的研究尚处于起始阶段，对其在银屑痛中的作用了解尚少肝素结合表皮生长因子样生长因子（HB-EGF）在银屑病表皮KC异常增殖和其转归中发挥重要作用。现对Th22细胞及其细胞因子与银屑病表皮表达HB-EGF的关系进行综述。

英文摘要：

Psoriasis is a common skin disease with unclear etiology that involves dysregulated interplay between immune cells and keratinocytes. Th22 cell was recently identified as another new subset of T cells, which produced IL-22. Th22 cells may participate in the pathogenesis of psoriasis. Heparin-binding epidermal-growth-factor-like growth factor （HB-EGF） plays an important role in keratinocyte hyperproliferation in psoriasis. The article has reviewed the correlation between Th22 cells and related cytokine and HB- EGF expression in psoriasis.