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Interactions of the HSV-1 UL25 Capsid Protein with Cellular Microtubule-associated Protein
  • 期刊名称：VIROLOGICA SINICA
  • 时间：0
  • 页码：211-217
  • 语言：英文
  • 分类：Q51[生物学—生物化学] Q26[生物学—细胞生物学]
  • 作者机构：[1]Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming 650118, China
  • 相关基金：Fundation items： National Natural Science Funds （30570081, 30670094 and 30700028）
  • 相关项目：HSVI蛋白α22在细胞基因转录调控过程中的生物学意义
作者： Ying Zhang|Qi-han Li|Wen-juan Wu|Lei Guo|Wei-zhong Li|Li-chun Wang|Yun Liao|Long-ding Liu|Yan-chun Che|
关键词： 衣壳, 蛋白质, 细胞, 萤光免疫检验法, 检验方法, HSV-1, Capsid, UL25, Microtubule-associated protein
中文摘要：

在 HSV-1 UL25 衣壳蛋白质和细胞的联系微导管的蛋白质之间的一个相互作用用酵母被发现二混血儿的屏幕和 β-D-galactosidase 活动试金。UL25 蛋白质的 Immunofluorescence 显微镜学在原生质膜与细胞的联系微导管的蛋白质表明了它的合作本地化。有缺失突变体的进一步的调查建议 UL25 是可能的在原子核有功能。

英文摘要：

An interaction between the HSV-1 UL25 capsid protein and cellular microtubule-associated protein was found using a yeast two-hybrid screen and β-D-galactosidase activity assays. Immunofluorescence microscopy of the UL25 protein demonstrated its co-localization with cellular microtubule-associated protein in the plasma membrane. Further investigations with deletion mutants suggest that UL25 is likely to have a function in the nucleus.

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