中文摘要：

肿瘤发生和发展与其代谢改变密切相关，而代谢改变会增加不利细胞生存的毒性代谢中间物，如糖酵解增强导致甲基乙二醛积累。研究发现，GLOⅠ可通过对细胞糖代谢过程中毒性代谢产物甲基乙二醛的降解来抑制肿瘤细胞凋亡，促进其生长。反过来，抑制GLOⅠ表达则积累细胞内甲基乙二醛，促使肿瘤细胞凋亡，从而达到抗癌效果。本文从GLOⅠ结构与功能、在肿瘤发生和发展中的作用以及临床应用等方面作了初步探讨。

英文摘要：

Tumor metabolic changes is closely related to the occurrence and progression of human malignancies.Meanwhileabnormal metabolism of tumor lead to the accumulation of cytotoxic metabolites such as methylglyoxal(intermediate products ofglycolysis),which are bad for cell survival.The research of recent years find that GLO I may inhibit the apoptosis of cancer cellthrough the degradation of the toxic metabolite methylglyoxal which is produced in the process of carbohydrate metabolism.Inreverse,the inhibition of the expression of GLO I will accumulate methylglyoxal in cell which leads to the apoptosis of cancer cell,thus achieve anticancer effect.This article makes some preliminary discussion on the structure and function of GLO I,its role in theoccurrence and development of tumor and relevant clinical appliance.