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中文摘要：
目的探讨持续气道正压通气（CPAP）对阻塞性睡眠呼吸暂停综合征（OSAS）患者唾液中氧化应激水平的影响。方法 42例重度OSAS患者接受CPAP治疗,于治疗前及治疗后1、6和12个月分别留取唾液标本;同时留取42例健康体检者唾液标本。所有唾液标本均采用酶联免疫吸附试验法（ELISA）进行晚期糖化终产物（AGEs）及果糖胺（FA）的测定。结果 OSAS患者经CPAP治疗后唾液中的AGEs和FA水平在第1、6及12个月时逐渐降低（P〈0.05）,而第12个月与正常对照组水平无统计学差异（P〉0.05）。结论唾液中氧化应激指标的变化对CPAP治疗OSAS的临床疗效观察可能具有潜在的参考价值。
英文摘要：
Objective To investigate The effect of continuous positive airway pressure on salivary markers of oxidative stress in patients with obstructive sleep apnea syndrome. Methods Patients with 42 severe OSAS received CPAP treat- ment,and saliva samples were taken before CPAP therapy as well as after 1,6 and 12 months of CPAP treatment; Mean- while, saliva samples of healthy controls were taken. Advanced glycation end products（AGEs） and fructosamine（FA） in all saliva samples were measured by enzyme linked immunosorbent assay（ELISA）. Results AGEs and FA levels of saliva in OSAS patients were gradually decreased in the 1,6 and 12 months after the CPAP therapy （P 〈 0. 05） ,whereas no signifi- cant difference between the first 12 months and the control group was found（P 〉 0. 05 ） . Conclusion Changes in oxida- tive stress indexes in saliva might have potential informative value for clinical observation on OSAS patients with CPAP ther- apy.
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