中文摘要：

目的 分析血浆同型半胱氨酸（HCY）与冠状动脉粥样硬化性心脏病（冠心病,CHD）的关系。方法 入选2011年1月至2014年12月在四川省科学城医院及华西医院拟诊为CHD并行冠状动脉造影术（CAG）患者120例,其中男性63例,女性57例,平均年龄（52.8±10.1）岁。三支冠状动脉至少一支血管病变狭窄≥50%者为研究组（92例）,后依据临床类型分为稳定型心绞痛（SAP）组（26例）、不稳定型心绞痛（UAP）组（31例）、急性心肌梗死（AMI）组（35例）。三支冠状动脉血管狭窄均〈50%者纳入对照组（28例）。根据Syntax评分将研究组细分为低危组（0-22分,18例）、中危组（23-32分,29例）和高危组（33分以上,45例）。检测各组血浆同型半胱氨酸（HCY）水平。结果 与对照组比较,研究组血浆HCY水平升高,高HCY血症比例增加,[（10.93±2.51）μmol/L vs.（21.93±5.54）μmol/L]、（14.28%vs.51.08%）,差异有统计学意义（P均〈0.05）。对照组、SAP组、UAP组及AMI组患者血浆HCY水平呈升高趋势,UAP组及AMI组明显高于对照组,数值为[（17.85±5.67）μmol/L vs.（10.93±2.51）μmol/L],[（24.56±5.03）μmol/L vs.（10.93±2.51）μmol/L],差异均有统计学意义（P均〈0.05）。低危组、中危组和高危组HCY水平均高于对照组,差异有统计学意义（P均〈0.05）。结论HCY水平与冠心病的发生和严重程度密切相关,检测HCY对于预防CHD有重要意义。

英文摘要：

Objective To analyze the relationship between homocysteine（Hcy） and coronary heart disease（CHD）. Methods CHD patients（n=120, male 63, female 7 and average age=52.8±10.1） undergone coronary angiography（CAG） were chosen from Jan. 2011 to Dec. 2014. All patients were divided into test group（n=92, with at least 1 coronary artery stenosis≥50% among 3 coronary arteries） and control group（n=28, with all 3 coronary artery stenosis50%）. The test group was divided, according to clinical types, into stable angina pectoris group（SAP group, n=26）, unstable stable angina pectoris group（UAP group, n=31） and acute myocardial infarction group（AMI group, n=35）, and divided, according to Syntax scores, into low-risk group（0-22 scores, n=18）, mid-risk group（23-32 scores, n=29） and high-risk group（over 33 scores, n=45）. The level of Hcy was detected in all groups. Results Compared with control group, the level of Hcy increased [（10.93±2.51） μmol/L vs.（21.93±5.54） μmol/L] and percentage of patients with hyperhomocysteinemia increased（14.28% vs. 51.08%） in test group（all P〈0.05）. The level of Hcy had a increasing trend in SAP group, UAP group and AMI group, and was significantly higher in UAP group and AMI group than that in control group [（17.85±5.67） μmol/L vs.（10.93±2.51） μmol/L,（24.56±5.03） μmol/L vs.（10.93±2.51） μmol/L, all P〈0.05]. The level of Hcy was higher in low-risk group, mid-risk group and high-risk group than that in control group（P〈0.05）. Conclusion The level of Hcy is closely related to the occurrence and severity of CHD, and detection of Hcy is significant to preventing CHD.