中文摘要：

目的 研究消瘀止血片对月经过多患者血小板膜糖蛋白Ⅰ bα（GP Ⅰ bα）和生活质量的影响.方法 80例排除妇科原因引起的月经过多的患者分为两个治疗组,每组各40例,分别给予消瘀止血片每次口服5片,每日3次;氨甲环酸片每次口服1 g,每日3次;连续治疗3个月经周期.所有患者用月经失血图统计月经量.另外40名健康女性作为正常组.用流式细胞学检测血小板膜上GP Ⅰ bα量,比浊法测定治疗前后血小板最大聚集率（MAR）.用焦虑自评量表评估患者治疗前后的生活质量.结果 消瘀止血片和氨甲环酸均能减少月经量（均P〈0.01）,消瘀止血片组优于氨甲环酸组（P=0.032）.两组患者GP Ⅰ bα的表达明显低于正常组（均P〈0.01）,MAR低于正常组（均P〈0.01）.消瘀止血片组治疗后GP Ⅰ bα明显上升（P=0.001）,较正常组无明显差异（P=0.368）;MAR较治疗前明显增加（P=0.047）,较正常组无明显差异（P=0.320）.氨甲环酸片组治疗后GPⅠbα无明显增高（P=0.283）,MAR较治疗前增加（P=0.030）,但与正常组仍有明显差异（P=0.032）.治疗后两组SAS评分较治疗前明显下降（P〈0.01,P=0.048）,消瘀止血片组优于氨甲环酸组（P=0.042）.结论 月经过多患者的血小板膜GP Ⅰ bα下降,导致血小板聚集功能下降.消瘀止血片治疗GP Ⅰ bα下调的月经过多患者有效,而且能改善这些患者的生活质量.

英文摘要：

Objective To investigate the effect of Xiaoyu Zhixue tablet （XYZXT） on the expression of platelet membrane glycoprotein （GP） Ⅰ bα and quality of life in patients with menorrhagia. Methods Eighty patients with menorrhagia excluding gynecological causes were randomly divided into two treatment groups with 40 patients in each group. They were treated with XYZXT （5 tablets once,3 times per day） or TXA （1 g once,3 times per day） for 3 menstrual cycles. Pictorial blood loss assessment chart （PBAC） was used to measure the menstrual blood loss. Another 40 healthy women were enrolled as control group. GPⅠ bα was assessed by flow cytometry. The maximum aggregation rate （MAR） of platelet was determined by turbidity method. Zung self-rating anxiety scale （SAS） was used before and after treatment to evaluate the quality of life of patients. Results The menstrual blood loss was reduced in both treatment groups, and XYZXT group had better efficacy than TXA group （P= 0. 032）. The expression of GPⅠ bα was markedly lower in menorrhagia patients than that in control group, with difference being statistically significant （both P〈0.01）. MAR was significantly decreased in the two treatment groups when compared with the control group （both P〈0.01）. After treatment,GPⅠ bα was increased in XYZXT group （P=0. 001） and there was no significant difference between XYZXT group and control group （both P= 0. 368）. Moreover, MAR in XYZXT group was significantly increased as compared to pre-treatment （P=0. 047） and no significant difference in MAR was found between XYZXT group and control group （P=0. 320）. In TXA group,GPⅠ bα had little increase and was not significantly different from that before treatment （P=0. 283） ;MAR was significantly increased after treatment （P= 0. 030） and there was significant difference between TXA group and control group （P=0. 0320）. SAS scores were reduced in both treatment groups （P〈0.01,P=0. 048） and XYZXT group was better t