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中文摘要：
目的探讨纳米粒子是否能从体内排出。方法将纳米活性炭（ACNP）或印度墨水经静脉注入动物体内，在注射后不同时间收取胆汁和尿液，在透射电镜下观察有无纳米粒子的排出。在停药后不同时间取动物肝脏、肠和肾脏等脏器组织进行光镜病理检查，提供纳米粒子是否可以从这些器官排出的佐证。结果经静脉注射的纳米粒子可随血液分布到肝脏、肠和肾脏等脏器组织中，胆汁及尿液中含有大量高密度粒子。结论纳米粒子可能随胆汁，尿液排出体外；肺，小肠，大肠可能是纳米粒子排泄的另外途径。
英文摘要：
OBJECTIVE To explore, the possible excretion pathways of nano-particles.METHODS Biliary and urinary samples were collected and prepared for transmission electron microscopy observation after activated carbon nano-particles （ACNP） and Indian ink （Ⅱ） were injected into rabit＇s vein. Meanwhile,liver, intestine and kidney were taken out and pathological sections were prepared for light microscopy observation.RESUTS The intravenous nano-partieles had wide distribution in animalis-liver, intestine and kidney and there were many nano-particles in bile and urine. CONCLUSION Nano-particales may be excreted through bile and urine. Lung, small intestine and large intestine may also be excretion pathways.
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