中文摘要：

目的 探讨和胃安神方对失眠大鼠血浆及下丘脑胆囊收缩素8（CCK-8）的影响.方法 将30只雄性wistar大鼠随机分为正常对照组、失眠模型组、和胃安神方中药组.采用放射免疫分析法检测血浆及下丘脑组织CCK-8的含量.结果 和胃安神方中药组血浆CCK-8含量为（19.320±4.577）pg/ml,高于模型组（12.924±5.132）pg/ml,差异有统计学意义（P〈0.05）,与正常组（23.718±6.917）pg/ml比较无显著性差异（P〉0.05）;和胃安神方中药组下丘脑CCK-8含量为（1.655±0.415）pg/mg,高于模型组（1.058±0.398）pg/mg,差异有统计学意义（P〈0.05）,与正常组（1.936±0.652）pg/mg比较无显著性差异（P〉0.05）.结论 和胃安神方治疗失眠症的疗效机制可能与其上调CCK-8水平有关.

英文摘要：

Objective To study the effect of Hewei Anshen Decoction （HWASD） on CCK-8 levels in plasma and hypothalamus of insomnic rats. Methods Thirty healthy male wistar rats were randomly divided into three groups：normal control group,insomnia model group and HWASD treatment group. Radio- immunoassav was used to measure the levels of CCK-8 in plasma and hypothalamus. Results The concentration of CCK-8 in the plasma of HWASD treatment group was （ 19. 320 ± 4. 577 ） pg/ml, significantly higher than that of insomnia model group （ 12. 924±5. 132） pg/ml （ P〈0.05 ）, similar to normal control group （23. 718±6. 917） pg/ml （P〉0.05）. The level of CCK-8 in the hypothalamus of HWASD treatment group was （ 1. 655 ±0. 415 ） pg/mg, significantly higher than that of insomnia model group（ 1. 058±0. 398） pg/mg （ P〈0.05 ）, similar to normal control group （ 1. 936-0. 652） pg/mg （ P〉 0. 05 ）. Conclusion The therapeutic effect of Hewei Anshen Decoction on insomnia is partially attributed to increased content of CCK-8.