中文摘要：

目的探究超广角荧光素眼底血管造影（ultra-widefield fluorescein angiography, UW-FA）的临床应用价值，比较UWFA与55°荧光素眼底血管造影（FFA）分别适用的眼底体征。方法回顾性分析2014年12月至2016年1月期间在中山大学中山眼科中心行海德堡UWFA及55°FFA的患者124例248只眼，对比分析UWFA和55°FFA所能显示的视网膜范围及对不同眼底病变的显示情况。结果超广角镜头一次可观察到150°眼底，单张UWFA图片的成像面积是单张55°FFA图片的3．2倍，配合患者的眼球转动，超广角镜头能更好地显示远周部视网膜，特别是能显示55°镜头难以拍摄到的鼻侧及下方远周部视网膜，五方位UWFA图片即可显示完整眼底。超广角镜头更适合拍摄累及周边视网膜的眼底病变，如视网膜周边变性、血管渗漏、无灌注区、微血管瘤、新生血管等；但其对后极部病灶细节的展现存在一定的不足。结论与传统55°FFA相比，UWFA能更好地显示远周部视网膜，简便高效地诊断及监测累及远周部视网膜眼底病变；55°FFA能更好地显示后极部病灶。在进行FFA检查时应根据不同的病变特征，个性化灵活选择镜头。

英文摘要：

Objective To study the clinical application of Heidelberg ultra-widefield fluorescein angiography （UWFA） and compare the feasibility of Heidelberg UWFA and Heidelberg 55° fundus fluorescein angiography （FFA） in visualizing fundus lesions peripherally and posteriorly. Methods A total of 124 consecutive patients （248 eyes） undergoing Heidelberg UWFA and 55°FFA in Zhongshan Ophthalmic Center during December 2014 to January 2015 were retrospectively analyzed. The view field areas and fundus lesions of FFA captured using Heidelberg ultra-widefield lens and Heidelberg 55° lens were compared. Results The UWFA imaging module visualized a 150° view field of the fimdus in a single photograph, which captured 3.2° the area captured by a single 55° FFA image. A five-field protocol of UWFA images was sufficient to cover the whole fundus. UWFA was superior in showing the far peripheral retina, especially in the nasal and inferior quadrants, which were diffi- cult to image using 55° FFA. Peripheral retinal lesions such as peripheral retinal degeneration, vascu- lar leakage, nonperfusion area, microaneurysm, and retinal neovascularization were better visualized using UWFA. However, UWFA failed to show the details of the posterior lesions. Conclusions Ap- propriate lens should be chosen based on the features of the studied lesion. UWFA is the optimal choice for imaging lesions at the far peripheral retina, enabling efficient diagnosis and monitoring of the fundus diseases involving the peripheral retina. 55° FFA is better in showing posterior retinal le- sions.