中文摘要：

糖尿病是一种受遗传和环境影响的多因素内分泌疾病,主要表现为以高血糖、高血脂和胰岛素抵抗为特征的代谢紊乱,其中90%~95%为2型糖尿病（非胰岛素依赖型糖尿病）。2型糖尿病严重危害人类健康,发病机制较为复杂,与多种酶和受体失调有着密切关联,如葡萄糖代谢中的关键酶α-葡萄糖苷酶、醛糖还原酶、葡萄糖激酶等,胰岛素信号通路中的酶及转录因子如糖原合酶激酶-3、核转录因子-κB等,与胰岛素分泌相关的钙通道和ATP敏感性钾通道、与胰岛素增敏相关的过氧化物酶增殖体激活受体等。因此,对糖尿病相关治疗药物作用靶点的研究,已经成为医药界的研究热点。

英文摘要：

Diabetes mellitus is one of multifactorial endocrine diseases,affected by generations and environment. It mainly manifests metabolic disorder characterized by hyperglycemia,hyperlipidemia and insulin resistance. 90% to 95% of people with diabetes have type 2 （non-insulin-dependent） diabetes mellitus （T2DM）, which seriously hazards human health. The underlying pathogenic mech- anism of T2DM is still elusive, which is closely associated with a variety of dysregulated enzymes and receptors, such as key enzymes in the metabolism of glucose （ alpha-glucosidase, aldosc reductase, glucokinasc, etc ） , enzymes and transcription factors in the insulin signaling pathway （ glycogen synthase Kinase-3, Nuclear factor-KB, etc. ） , calcium channels and ATP-sensitive potassium channels with relation to insulin secretion and peroxisome proliferator-activated receptors increasing insulin-sensitizing. Therefore, the study of anti-diabetic therapeutic agent targets has become a research hotspot recently.