中文摘要：

目的了解黏液型铜绿假单胞菌对常用抗菌药物的体外敏感性变迁,为临床规范的进行抗感染治疗提供流行病学依据。方法回顾性分析2012-2014年住院患者感染黏液性铜绿假单胞菌的检出率,采用VITEK-2-MS鉴定仪及ATB PSE板条检测8种抗菌药物的体外药敏结果,数据采用WHONET5.6软件进行统计分析。结果 2012-2014年住院患者中共检出铜绿假单胞菌2 520株,其中黏液型铜绿假单胞菌278株,占11.03%;黏液型铜绿假单胞菌主要分离自痰液261株占93.89%、其次为尿液6株占2.16%;黏液型铜绿假单胞菌对头孢他啶、庆大霉素、阿米卡星的敏感率均〉60.00%,其中对阿米卡星的敏感率最高,为83.09%,而对头孢吡肟、环丙沙星敏感率为50.00%~60.00%,对美罗培南耐药率最低,为12.59%,而对亚胺培南的耐药率为22.66%,明显高于美罗培南;多药耐药菌检出率为22.30%。结论黏液性铜绿假单胞菌对8种常用抗菌药物的耐药性高,虽然2012-2014年黏液型铜绿假单胞菌对8种常用抗菌药物耐药性未见明显增加,多药耐药率保持稳定,但临床应合理使用抗菌药物,避免多药耐药菌株的产生。

英文摘要：

OBJECTIVE To investigate the antibiotic susceptibility in vitro of mucoid Pseudomonas aeruginosa to 8anti-pseudo antibiotics,and to provide epidemiological evidence for clinical anti-infective treatment.METHODS The WHONET5.6software was applied to analyze its prevalence and antibiotic susceptibility C（ATB PSE5）of inpatients from 2012 to 2014retrospectively.RESULTS A total of 2520non-duplicated P.aeruginosa were isolated with 278 mucoid P.aeruginosa（11.03%）from the inpatients from 2012 to 2014.Most of mucoid P.aeruginosa were from sputum with 261strains（93.89%）,followed by 2strains from urine（2.16%）.The sensitivity rates of mucoid P.aeruginosato ceftazidime,gentamicin,amikacin were all greater than 60.00%.The susceptible rate of amikacin was 83.09%,of cefepime and ciprofloxacin was 50.00%~60.00%,of meropenem was 12.59%,while of imipenem was 22.66% which was significantly higher than that of meropenem.The detection rate of multi-drug resistant bacteria was 22.30%.CONCLUSION Drug resistance of mucinous P.aeruginosato eight kinds of commonly used antimicrobial is high.Although Drug resistance from 2012 to 2014has no significant increase,the clinical use of antibiotics should be reasonable in order to avoid the existence of multi-drug resistant strains.