中文摘要：

目的：系统评价与比较中药疗法与单纯西药疗法治疗胃癌前病变的临床疗效。方法：通过制定检索策略和对国内、外数据库检索及手工查阅，两名评价人员对符合纳入标准和排除标准的随机对照试验进行独立筛选，对所纳入研究的文献进行有效的数据提取和统计合并，并对文献质量进行方法学评价，根据异质性分析选用固定效应模式进行系统分析。结果：共有4篇随机对照试验纳入研究，中药疗法的综合疗效为[RR=1．52，95％CI（1．27，lJ82）】；中药疗法对中、重度异型增生的改善情况分别为[RR=1．58，95％CI（1．09，2．29）]和[RR=2．14，95％CI（0．84，5．41）]；中药疗法对癌前病变的改善情况为[RR=1．85，95％CI（1.35，2．54）]。结论：Meta分析显示中药疗法对胃癌前病变的综合疗效、改善中度异型增生和改善癌前病变方面优于单纯西药治疗，但中药治疗在改善重度异型增生上尚不能认为优于单纯西药治疗。由于纳入研究的文献较少且部分文献为低质量偏倚风险不确定的随机对照研究，尚需高质量和低偏倚风险的研究进一步证实。

英文摘要：

OBJECTIVE： To evaluate and compare clinical efficacy between traditional Chinese medicine （TCM） and western medicine alone for precancerous lesions of gastric cancer （PLGC）. METHODS： After establishing searching strategy, retrieving from domestic and foreign database and researching by hand, two authors independently identified RCTs according to exclusion and inclusion criterion. The data of included studies was extracted and summarized. The quality of literatures was evaluated, and fixed-effects model was adopted for systematic analysis according to heterogeneity analysis. RESULTS ： A total of 4 RCTs were in- cluded. Therapeutic efficacy and the improvement of symptoms were as follows： comprehensive efficacy of TCM therapy [RR---- 1.52,95 % CI（1,27,1.82） ], the improvement of moderate and severe dysplasia by TCM therapy [RR---- 1.58,95 % CI（ 1.09,2.29）] and [RR=2.14, 95% CI （0.84, fi.41）], the improvement of PLGC[RR= 1.85, 95% CI （1.35,2.54）]. CONCLUSIONS： Results of Me- ta-analysis shows that TCM therapy is better than western medicine alone in respects of comprehensive efficacy of PLGC, the im- provement of moderate dysplasia and PLGC. But TCM therapy can not be considered as better therapy then western medicine alone in the treatment of severe dysplasia. Further randomized trials with high-quality and low-risked bias is needed because few trials have been included and part of them are low-quality and unconfirmed low-risk bias RCTs.