中文摘要：

目的：研究复方当归汤含药肠吸收液舒张血管平滑肌的作用。方法：取大鼠小肠制成翻转囊,置于复方当归汤粗提液中温孵2 h,取肠囊内K-R液即得复方当归汤含药肠吸收液。采用大鼠离体胸主动脉环灌流模型,观察累积浓度含药肠吸收液对基础状态、苯肾上腺素（PE）预收缩、氯化钾预收缩血管环的作用,并与硝苯地平比较。结果：复方当归汤含药肠吸收液对基础状态或氯化钾预收缩的血管环无明显影响;当含药肠吸收液中指标成分阿魏酸浓度累积达2.48×10-3,4.96×10-3,9.92×10-3g.L-1时,可剂量依赖性抑制PE预收缩的血管环收缩（P〈0.05）。硝苯地平对基础状态预收缩的血管环无明显影响;当浓度累积达8.66×10-4,17.32×10-4,34.65×10-4mmol.L-1时,可剂量依赖性抑制PE或氯化钾预收缩的血管（P〈0.05,或P〈0.01）。结论：复方当归汤含药肠吸收液对完整内皮的PE预处理的血管有舒张作用,含药肠吸收液可用于中药复方离体药效学研究。

英文摘要：

Objective： To investigate relaxant effect of Compound Danggui decoction （DGD） -containing intestinal absorption on vascular rings of thoracic aorta in rats. Method： The everted gut sac was prepared using intestinal of rats, then was immersed into the crude extractive solution of compound DGD, the K-R solution inside the sac was collected as the intestinal absorption of DGD after 2 hours incubation. The study was performed with the model of rat isolated thoracic aorta rings in organ bath. The effect of accumulated DGD on aorta rings in resting tension, or pre-constricted with KC1, or pre-constricted with phenylephrine （PE） was observed, and were compared with nifedipine, Result： DGD had no significant effects on aorta rings in resting tension or pre- constricted with KC1. When the concentration ration of ferulic acid in DGD was cumulated to 2.48 ×10 -3, 4.96 ×10-3, 9.92 ×10-3 g.L-1, it caused concentration-dependent relaxation while aorta rings were pre-constricted with PE. Nifedipine had no significant effects on aorta rings in resting tension, when the concentration ration of nifedipine was cumulated to 8.66 ×10-4, 17.32 ×10-4, 34.65 ×10-4 mmol. L-1 , it caused concentration- dependent relaxation while aorta rings were pre-constricted with PE, or pre-constricted with KC1. Conclusion： Intestinal absorption of compound DGD can relax the rat thoracic aorta rings with endothelium. The results indicate that intestinal absorption containing drugs may be used to pharmacodynamic study in vitro.