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中文摘要：
表面增强拉曼散射（SERS）被用于检测细菌芽孢中的一种重要的标志物吡啶2,6-二羧酸（DPA）。以聚乙烯吡咯烷酮（PVP）为粘合剂,将60 nm的金粒子组装到表面打磨光滑的金电极上,制备稳定、灵敏的SERS基底。通过不同pH值下吸附在金基底上的DPA的SERS特征,考察DPA分子吸附构型发生的变化,并分析酸根离子对其吸附的影响。结果表明：在强酸条件下,DPA在Au NPs/PVP/Au基底上的SERS信号能达到最大增强;当pH值大于DPA二级解离常数时,DPA的SERS特征逐渐减弱。在DPA中引入不同酸根盐时,后者会取代纳米金表面的柠檬酸根所占的部分位点,改变Au NPs-Au基底的SERS增强性能。3种酸根吸附性能不同,所以获得的光谱强度存在差异。
英文摘要：
Surface enhanced Raman scattering（SERS） was used for the detection of 2,6-pyridinedicarboxylic acid（DPA）,a biomarker for bacterial spores.The gold nanoparticles of 60 nm diameters were immobilized on a polished Au electrode using PVP as an adhesive layer.We demonstrated that the fabricated SERS substrates were steady and highly sensitive.The influence of pH and anions about the adsorption mechanism of DPA on colloidal gold nanoparticles has been examined by SERS.The results showed that using a gold nanoparticle/polyvinylpyrrolidone/gold substrate（AuNPs/PVP/Au） for detection of DPA exhibited a maximum enhancement of SERS signal at low pH,however the SERS features and intensity of DPA were found to weaken when pH was greater than pKa2.The effect of different anions on the adsorption mechanism of this molecule was also investigated,the SERS effect on Au NPs-Au substrate had changed,since the anions may replace the partial sites of the citrate on the gold surface.Owing to the different adsorption mechanism of the three anions,the difference of SERS intensity was observed on the addition of different anions.
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