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中文摘要：
目的研究尖锐湿疣亚临床感染（SPI）转归与局部T淋巴细胞亚群变化的关系，进一步探讨SPI转归机制。方法对确诊的SPI患者进行：①所有患者随访8个月，每月观察1次，以临床表现和醋酸白试验判定SPI三种转归结局：发展为典型CA，SPI持续存在、SPI消失，依次分为A组、B组、C组；②免疫组织化学方法检测皮损组织和正常对照组织的T细胞亚群（CD4＋，CD8＋，CD4＋／CD8＋）的百分比，分析局部细胞免疫功能与三种转归结局的相关性。结果与正常组比较，SPI组CD；细胞、CD8＋细胞、CD4＋／CD8＋比值差异均有统计学意义（P〈0．05）。SPI转归组中，A组与B组CD4＋／CD8＋比值差异无统计学意义（P〉0．05），A组、B组分别与c组比较c02／CD8＋比值差异均有统计学意义（P〈0．05）。结论SPI患者存在局部细胞免疫功能降低，局部细胞免疫功能强弱是决定SPI临床症状及转归的重要因素之一。
英文摘要：
Objective To study the relationship between host local T-lymphocyte subsets and the outcome of subclinical human papillomavirus infection （SPI） in patients with Condyloma acuminatum, so as to further study the mechanism of SPI. Methods Sixty-two diagnosed SPI patients were included： All patients had been followed up for eight months, and observed once a month. Three outcomes of SPI were determined through clinical observation and acetowhite test, consisting of developing into typical CA, continuing SPI, and disappeared SPI. All patients were divided in turn into group A, B and C. T lymphocyte subsets （CD4 , CDs , CD4＋/CDs＋ ） in lesions and normal skins were detected by immunohistochemical staining. The correlation between local cellular immune functions and the three outcomes of SPI were analyzed by t test. Results The CD4＋ cells, CDs cells and CD4/CDs ratio between normal control group and SPI group had significant statistical differences （P 〈 0. 05 ）. CD4/CDs ratio between group A group B didn＇t show significant statistical differences （ P 〉 0 . 05 ）, while significant differences （ P 〈 0. 05 ） were observed between group A and group C, group B and group C. Conclusion SPI patients have imparied local cellular immune function. The strength of local cellular immunity is an important factor to determine SPI patients＇ clinical symptoms and outcomes.
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