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Serum Low-Density Lipoprotein and Heart Rate Related to the Effectiveness in the Treatment of Angina Pectoris with Two Similar Chinese Medicine Herbal Formulae

ISSN号：1003-6326
期刊名称：《中国有色金属学报：英文版》
时间：0
分类：Q513.5[生物学—生物化学] S858.2[农业科学—临床兽医学;农业科学—兽医学;农业科学—畜牧兽医]
作者机构：[1]Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing （100700）, China, [2]Peking University First Hospital, Beijing （100034）, China, [3]E-Institute of Shanghai Municipal Education Commission, Shanghai University of Traditional Chinese Medicine, Shanghai （201203）, China
相关基金：Supported in Part by Projects from National Science Foundation of China （No. 90209002 and 30825047）, and E-Institutes of Shanghai Municipal Education Commission （No. E03008）

作者： YAN Shi-yan[1], yAO chen[2], DING Xiao-rong[1], JIANG Miao[1], LU Ai-ping[1,3]

关键词：低密度脂蛋白, 配方治疗, 心绞痛, 心率, 血清, 中医药, 草药, 类似, angina pectoris, qi deficiency and blood stasis syndrome, Chinese medicine, low-densitylipoprotein, heart rate

中文摘要：

探索有效性的目的联系了可能帮助识别 Tongxinluo 囊的指示的指示物() 并且 Kangxin 囊() 在心绞痛的治疗在中国药(厘米) 在 qi 缺乏和血壅滞模式上指向。

英文摘要：

Objective： To explore the effectiveness related indicators which might help identify the indications of Tongxinluo Capsule （通心络胶囊） and Kangxin Capsule （康欣胶囊） targeting on qi deficiency and blood stasis pattern in Chinese medicine （CM） in the treatment of angina pectoris. Methods： The data from a multicenter, randomized and double-blinded study conducted at 5 centers in China were obtained for the analysis. A total of 239 patients with angina pectoris and CM syndrome of qi deficiency and blood stasis were randomly assigned in a 1：1 ratio to Tongxinluo Capsule group （119 cases） and Kangxin Capsule group （120 cases）. Angina effectiveness and electrocardiogram （ECG） improvement were selected as the therapeutic outcomes. Results： After a 4-week treatment, the effective rates of Tongxinluo Capsule and Kangxin Capsule were 43.70% and 25.00%, respectively （P〈0.05）. Serum low-density lipoprotein （LDL） level was found to influence the effectiveness of Tongxinluo Capsule which had higher effective rate in the patients with lower level of LDL. Heart rate was found to influence the effectiveness in the patients treated with Kangxin Capsule which had higher effective rate in the patients with heart rate ≤80 beats/min. Conclusion： LDL level and heart rate were the indicators which help indentify the indications of Tongxinluo Capsule and Kangxin Capsule, respectively, in the treatment of angina pectoris with CM syndrome of qi deficiency and blood stasis.

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