中文摘要：

胰腺癌为消化道较常见的恶性肿瘤。针对胰腺癌特异性诊断探针和靶向治疗的药物研究包括抗体、亲和体、多肽以及小分子化合物抑制剂，其中针对蛋白激酶的小分子抑制剂的研究备受关注。笔者综述了这一方向的PET示踪剂的研究进展，其中H-89作为异喹啉磺酰基类小分子化合物，可能是最好的胰腺癌蛋白激酶小分子抑制剂之一，用正电子核素标记后，可能成为较有潜力的胰腺癌PET示踪剂。

英文摘要：

Pancreatic cancer is one of the most common malignancies of digestive tract. The targeted therapeutic drugs and specific diagnostic probes for pancreatic cancer include antibodies, affinity ligands, polypeptides, and small-molecule protein kinase inhibitors. The research on small-molecule protein kinase inhibitors is a hot topic of both preclinical research and clinical application in recent years. The advances in this area were briefly reviewed in this article. Data indicated that H-89, a kind of isoquinoline sulfonamide small molecule, might be one of the best small-molecule protein kinase inhibitors to treat pancreatic cancer, and if labeled with positron emitter, it might become a potential PET tracer for pancreatic cancer.