中文摘要：

目的：观察胃癌组织淋巴管结构和分布特点，探讨微淋巴管密度（LMVD）与肿瘤淋巴转移的相关性。材料和方法：临床各期胃癌患者，施行胃癌切除术获得胃癌癌周组织和正常区胃组织标本切片，VEGFR-3抗体免疫组化染色，标记淋巴管，计数组织中LMVD。依据临床病理特征分析LMVD变化。结果：胃癌癌周组织与正常区组织石蜡切片各56例，在癌周区处于开放状态的功能性微淋巴管增多。胃癌癌周组织LM-VD（22．10±6．99个／HP×200）较远离癌肿区正常胃组织LMVD（10．63±1．90个／HP×200）增多（P=0．000）。胃癌癌周LMVD与淋巴转移、肿瘤大小和分期有关（P〈0．05），与分型和是否侵及浆膜无关（P〉0．05）。结论：胃癌癌周LMVD与肿瘤大小、分期和淋巴转移有密切关系，可以作为肿瘤诱导生成淋巴管研究的量化指标，有助于胃癌的预后判断及治疗方案的评价。

英文摘要：

Objective： To investigate the relationship between lymphatic microvessel density （LMVD） and clinical pathology of gastric emeinoma. Methods： The expression of VEGFR - 3 in 56 gastric cancers （GC） was detected by inununohistoehemistry （SABC）, by which the LMVD was calculated. Results： The lymphangiogenesis was shown in peritumoral tissue in GCs. The LMVD of peritumoral tissue in GCs （22.10 ±6.99） was significantly higher than that of normal gastric tissue （ 10.63 ± 1.90） （ P = 0.000）. LMVD with lymphatic metastasis （25.43 ± 6.33） was higher than that without lymphatic metastasis （ 16.10 ± 2.93） （P=0,000）. LMVDinpTNM Ⅲ ＋Ⅳ （24.88±6.71） was higher than that in pTNM Ⅰ ＋ Ⅱ （16.22±2,50） （P=0.000）. LMVD with big tumor lymphatic metastasis （25.43 ± 6.33） was higher than those without lymphatic metastasis （ 16.10 ± 2.93） （P=0.000）, LMVDin pTNM Ⅲ ＋Ⅳ （24.88±6.71） was higher than that in pTNM Ⅰ ＋ Ⅱ（16.22±2.50） （P= 0.000）, LMVD with big tumor （diarneter≥5cm） （27.18 ± 6.95） was higher than those with small tumor （diameter〈 5cm） （ 19.28 ± 5,33） （ P = 0.002）. There was no significant difference between LMVD and the tumor size and histopathologie type of cancer. （P 〉 0.05）. Conclusion： LMVD in GCs showed oositive relations with pTNM stage and lymphatie metastasis.