中文摘要：

目的探讨免疫调理对慢性阻塞性肺疾病（COPD）合并多脏器功能障碍患者的治疗作用。方法 120例COPD患者分为健康对照组与急性期COPD试验组各60例;对照组进行常规治疗,试验组在第1天开始皮下注射胸腺肽α1,同时使用乌司他丁;两组在治疗的第1、3、7天时分别检测T细胞亚群和血细胞及CRP的水平,并观察两组患者住院时间、机械通气时间、28d病死率及住院费用。结果患者hs-CRP浓度为（45.17±39.96）ml/L,明显高于健康对照组的（1.19±2.04）ml/L,差异具有统计学意义（P〈0.05）;COPD急性期中性粒细胞计数为（7.03±3.53）×109/L,较缓解期（6.31±2.67）×109/L高,差异有统计学意义（P〈0.05）;试验组平均住ICU时间及使用呼吸机时间均较对照组明显缩短,差异有统计学意义（P〈0.05）,两组患者死亡率及住ICU治疗费用比较差异无统计学意义。结论应用胸腺肽α1及乌司他丁对COPD患者的免疫功能的影响,可从多方面减轻全身炎症反应对组织器官造成的损伤,保护器官功能,缩短住院时间和机械通气时间,降低病死率、感染率及住院总费用。

英文摘要：

OBJECTIVE To investigate the therapeutic effect of immune conditioning in COPD patients with multiple organ dysfunction.METHODS 120 patients with COPD were divided into healthy control and acute COPD experimental group（60 cases each）.Conventional treatments were performed in control group;for experimental group,thymosin α1 was subcutaneous injected from day 1（2 times a day,each 1.6 mg） combined with ulinastatin（200,000 units,simultaneous,2 times a day）.The course of treatment was 7 days.T-cell subsets,blood cell and CRP levels were determined in day 1,3 and 7;hospitalization time,mechanical ventilation,28-day mortality and hospital costs were observed.RESULTS T cell subsets,blood cell counts and CRP levels were statistically significant between the two groups;ICU stay and invasive mechanical ventilation time were significantly short in experimental group than the control group（P〈0.05）;no significant difference was found in treatment costs.CONCLUSION Application of thymosin α1 and ulinastatin in patients with COPD may reduce the systemic inflammatory response which can lead to the damage of a wide range of tissues and organs,protect organ function,shorter hospitalization time and mechanical ventilation,reduce the 28 days mortality,reduce the incidence of infection,and reduce the total cost of hospitalization.