中文摘要：

一氧化氮合酶在冠心病病理进程中有着重要的作用。一氧化氮合酶有3种亚型：神经型一氧化氮合酶（nNOS或NOS 1）,内皮型一氧化氮合酶（eNOS或NOS 3）,诱导型一氧化氮合酶（iNOS或NOS 2）。过去认为只有eNOS参与调控血管功能,然而最近众多的研究发现,nNOS表达于血管内皮并且在心血管系统内发挥重要作用。nNOS可以产生一氧化氮（NO）和过氧化氢（H2O2）等物质来调节非神经细胞的信号通路。本文将重点探讨nNOS在冠心病中的研究进展。

英文摘要：

Nitric oxide synthase plays an important role in the process of coronary atherosclerotic heart disease. Nitric oxide synthase has three subtypes： Neuronal nitric oxide synthase （nNOS or NOS 1）, endothelial nitric oxide synthase （eNOS or NOS 3）, and inducible nitric oxide synthase （iNOS or NOS 2）. In the past, only eNOS was thought to be involved in the regulation of vascular function, however, many recent findings suggest that nNOS expresses in vascular endothelial and plays an important role in the cardiovascular system. Activation of nNOS can produce NO, H2O2 and other substances to adjust the signaling pathway of non-neuronal cells. This article will focus on the research progress of nNOS in coronary heart disease.