中文摘要：

哺乳动物雷帕霉素靶蛋白（mammalian target of rapamycin,mTOR）是一种丝/苏氨酸蛋白激酶,在调节细胞的生长、增殖和存活中起着重要的作用。mTOR信号通路失调与许多衰老相关重大疾病如神经退行性病变、代谢综合征、肿瘤、心血管疾病等的发生发展密切相关,故对mTOR信号通路在衰老及衰老相关疾病中的作用机制的研究,对于揭示衰老及衰老相关疾病的发生机制具有重要意义,并为研发以mTOR信号通路为靶点的抗衰老及衰老相关疾病的治疗药物提供新策略。

英文摘要：

Mammalian target of rapamycin （mTOR）, a serine / threonine protein kinase, plays important roles in regulating cell growth, proliferation and survival, mTOR dysregulation is involved in many age-related diseases （such as nenrodegenerative diseases, metabolic syndrome, cancer and cardiovascular disease）. It is essential to explore the regulatory mechanism of mTOR in aging and aging related diseases, which will help us to understand the pathogenesis of these diseases, and provide new strategies for treatment with them.