中文摘要：

目的 探讨血清中瘦素（Leptin）、分泌型卷曲相关蛋白5（SFRP5）和视黄醇结合单核蛋白4（RBP4）表达水平与冠状动脉粥样硬化性心脏病（CAD）的关系。方法 选取71例怀疑为CAD的患者,根据心电图、冠脉造影等分为CAD组和非CAD组,收集患者临床资料,并用ELISA法分别测定血清Leptin、SFRP5、RBP4的表达水平,将Leptin、SFRP5、RBP4表达水平与CAD患者临床资料进行相关性分析。结果CAD组血清SFRP5水平明显低于非CAD组（P〈0.05）,Gensini积分与血清SFRP5水平呈负相关性（r=-0.20,P=0.01）;CAD组Leptin水平高于非CAD组,差异有统计学意义（P〈0.05）,血清RBP4水平在CAD组和非CAD之间差异无统计学意义。结论 Leptin、SFRP5表达水平的变化可能是CAD发生、发展的机制之一,可以作为预防、评估和治疗CAD的一个新靶点。

英文摘要：

Objective To investigate the relationship between serum Leptin, SFRP5 and RBP4 expression levels and coronary atherosclerotic heart disease （CAD）. Methods 71 patients suspected for CAD were included in the study and were divided into CAD and non-CAD group according to electrocardiogram and coronary angiography results. Serum Leptin, SFRP5 and RBP4 levels were examined using ELISA. Correlations of Leptin, SFRP5 and RBP4 expression levels and patients dermography such as CAD were analysed. Results Serum SFRP5 level in CAD group was significantly lower than in non-CAD group（ P 〈 0. 05 ）. Serum SFRP5 level was negatively correla- ted with Gensini score（r = -0 20 ,P = 0. 01）. In CAD group, serum Leptin level increased significantly compared with non-CAD group （P 〈0. 05）. There was no significant difference for serum RBP4 levels between CAD and non- CAD group. Conclusion The expression levels of Leptin, SFRP5 may be one of the mechanisms of initiation, development of CAD, which can be used as a new target for the prevention, assessment and treatment of CAD.