中文摘要：

目的探讨原发性高血压伴急性脑梗死患者的心率变异性（heart rate variability,HRV）和血压变异性（blood pressure variability,BPV）。方法收集原发性高血压合并急性脑梗死患者82例、单纯原发性高血压患者108例,进行动态心电图和动态血压同步测量,计算机自动计算HRV和BPV各指标。结果脑梗死组HRV各指标均低于单纯高血压组,且差异有统计学意义（P〈0.05）;夜间血压下降率脑梗死组均低于单纯高血压组,BPV各指标脑梗死组均高于单纯高血压组,其中夜间舒张压下降率、24 h平均收缩压（24 h SBP）和24 h收缩压变异系数（24 h SCV）两组差异有统计学意义（P〈0.05）。结论与单纯原发性高血压患者相比,原发性高血压合并急性脑梗死患者自主神经功能受损明显。随访观察HRV和BPV指标的变化对高血压及高血压合并急性脑梗死患者的病情评估及改善预后有一定的临床意义。

英文摘要：

Objective To investigate the heart rate variability（ HRV） and blood pressure variability（ BPV） in patients with essential hypertension complicating acute cerebral infarction.Methods A total of 82 patients with essential hypertension complicating acute cerebral infarction and 108 patients with pure essential hypertension were enrolled in our study.Their ambulatory electrocardiography and ambulatory blood pressure were measured synchronously.Indices of HRV and BPV were calculated by computer automatically.Results Compared with pure essential hypertension group,the value of each HRV index was lower in cerebral infarction group,with statistically significant difference（ P〈0.05）.In cerebral infarction group,the descending rate of nocturnal blood pressure was lower than that in pure essential hypertension group while the value of each BPV index was higher.And there were statistically significant differences（ P〈0.05） in the descending rate of nocturnal diastolic blood pressure,24-hour average systolic blood pressure（ 24 h SBP） and 24-hour systolic blood pressure coefficient of variation（ 24 h SCV） between the two groups.Conclusion The autonomic nervous function of the patients with essential hypertension complicating acute cerebral infarction is significantly impaired if compared with the cases attacked by pure essential hypertension.Itis clinically significant for evaluating severity and improving prognosis of hypertensives and those complicating acute cerebral infarction to make tracing observation on changes of HRV and BPV indices.