中文摘要：

以乙二胺四乙酸酐（ethylenediaminetetraacetic dianhydride，EDTAD）和丁二胺（butanediamine，BDA）为原料，通过酸酐的N-酰化开环聚合反应合成主链含酰胺基、侧链含羧基的直链共聚物（pEDTAD—BDA），然后在磷酸催化剂存在下，pEDTAD—BDA在160℃发生分子内脱水形成含多元酰亚胺的共聚物（pEDTAD—BDA—Imide），最后以丁二胺为交联剂，与pEDTAD—BDA—Imide中的酰亚胺发生N-酰化开环反应，生成了侧链含氨基的网络聚合物（BDA—crosslinked—EDTAD—BDA）。该网络聚合物可同时具有完全可降解性、pH敏感性和生物相容性。采用红外光谱和茚三酮显色法对pEDTAD—BDA和BDA—crosslinked—EDTAD—BDA的结构和分子量进行了定性定量表征。

英文摘要：

A novel pH-sensitive degradable hydrogel based on ethylenediaminetetraacetic dianhydride （EDTAD） was synthesized. EDTAD reacted with butanediamine through N-acylation ring-opening polymerization of anhydride groups to give a linear copolymer （pEDTAD-BDA） with carboxyl groups on its side chains and amide groups on its backbone, pEDTA-BDA was dehydrated between those carboxyl groups on its side chains and amide groups on its backbone at 160℃with phosphoric acid as a catalyst. A copolymer was produced containing imide groups （pEDTAD-BDA-Imide）. pEDTAD-BDA-Imide was crosslinked by BDA via N-acylation of the imide groups, yielding the desired network polymer with pendant amino groups （BDA-crosslinked-EDTAD-BDA）. BDA-crosslinked-EDTAD-BDA is a promising hydrogel for drug controlled release integrating such advantages as degradahility, good hiocompatihility and pH- sensitivity. FTIR and ninhydrin reaction are employed to qualitatively and quantitatively characterize pEDTAD-BDA and BDA-crosslinked-EDTAD-BDA.