目的观察加味麻杏甘石汤联合抗生素治疗社区获得性肺炎(痰热壅肺证)疗效及对C反应蛋白(CRP)的影响。方法 80例患者随机分为治疗组和对照组,各40例。对照组给予注射用头孢哌酮钠舒巴坦钠治疗。治疗组在抗生素治疗基础上予以加味麻杏甘石汤治疗。两组疗程为7~14 d,主要呼吸道症状和热退明显改善后3 d,可停止用药,结束本研究。结果治疗组愈显率77.50%高于对照组的62.50%(P〈0.05)。治疗后,治疗组在咳嗽、咯痰、退热、肺部啰音消失时间方面均低于对照组(均P〈0.01)。治疗前两组血清CRP水平差别不大(P〉0.05)。两组治疗后血清CRP水平与治疗前比较均降低(P〈0.01),且治疗组血清CRP水平低于对照组(P〈0.01)。结论加味麻杏甘石汤联合抗生素治疗社区获得性肺炎(痰热壅肺证)能够显著提高临床疗效,缩短退热、咳嗽和咯痰消失时间、肺部啰音消失时间,且能降低血清中CRP水平。
Objective: To observe additional Maxingganshi Decoction combining with antibiotic treating on the effect and the C-reactive protein.in community-acquired pneumonia with phlegm-heat obstructing lung type.Methods: 80 cases of CAP were randomly divided into the treatment group and the control group. The control group were given cefoperazone sodium and sulbactam sodium injection,and the treatment group were also given above injections while plus additional Maxingganshi Decoction. The course of treatment was lasted for 7 ~14 d.Depending on the improvement of respiratory symptom and fever relieving,therapy was stopped 3 days after significant effect. Results: The total effective rate was 77.50% in treatment group while 62.50% in control group with significant differences(P 0.05). Levels of coughing,expectoration,fever relieving and rale disappearing time in the treatment group after treatment were lower than those in the control group with significant differences(P 0.01). Levels of C-reactive in the treatment group after treatment were lower than that in the control group with significant differences(P 0.01). Conclusion: Additional Maxingganshi Decoction combining with antibiotic treating community-acquired pneumonia can shorter the period of fever relieving,coughing,expectoration and rale disappearing time,and can decrease the level of C-reactive protein.