目的:探讨社区老年人群肱踝脉搏波传导速度( brachial-ankle pulse wave velocity ,baPWV)与代谢综合征( metabolic syndrome , MetS)的关系及其性别差异。方法:2009年9月至2010年6月采用随机整群抽样,对北京市万寿路地区≥60岁老年人群进行横断面调查,MetS诊断采用2009年国际统一标准。结果:共纳入2102名(其中男性848名,女1254名)社区老年人,年龄60~95(67.9±5.8)岁。 MetS患病率为59.1%,其中男性为50.1%,女性患病率高于男性,为65.2%(P<0.001)。 baPWV 8.2~45.6(20.0±4.4) m/s,且随着年龄逐渐增加(P<0.001)。相关分析的结果显示,baPWV与体重指数(r=0.076,P=0.037)、收缩压(r=0.380,P<0.001)、舒张压(r=0.276,P<0.001)、甘油三酯(r=0.040,P=0.046)、空腹血糖(r=0.140,P<0.001)、餐后2小时血糖(r=0.121,P<0.001)呈正相关,与高密度脂蛋白胆固醇呈负相关( r=-0.128,P=0.048)。女性人群中, MetS的患病率、MetS组分数目随着baPWV数值增高逐步增加(趋势χ2检验P<0.05),而男性人群中增加趋势不显著。将baPWV水平按照四分位数进行分组,采用多因素Logistic回归分析,结果显示,以baPWV数值最低的一组作为参照组,第2组、第3组和最高组对MetS的OR值在男性和女性人群中分别为1.22(95%CI 0.83~1.79)、1.32(95%CI 0.90~1.93)、1.46(95%CI 1.00~2.14)和1.28(95%CI 0.93~1.77)、1.55(95%CI 1.12~2.16)、1.86(95%CI 1.32~2.61),趋势χ2检验P<0.05。结论:社区老年人群baPWV水平与MetS显著相关,尤其在女性人群中。
Objective:To evaluate the association between brachial-ankle pulse wave velocity ( ba-PWV) and metabolic syndrome ( MetS) among the Chinese elderly and the gender difference .Methods:We conducted a population-based cross-sectional study in a representative urban area of Beijing , China. A sample of 2 102 community elderly (848 males, and 1 254 females) aged 60 to 95 years were included in the study .MetS was defined according to the 2009 harmonizing definition .Results:The prevalence of MetS was 59.1% (50.1% in males and 65.2% in females, P〈0.001).The baPWV value was be-tween 8.2 to 45.6 (20.0 ±4.4) m/s, and showed an increasing trend with age (P〈0.001).The par-tial correlation showed baPWV was positively associated with BMI (r =0.076, P =0.037), systolic blood pressure (r=0.380, P〈0.001), diastolic blood pressure (r=0.276, P〈0.001), triglyceride (r=0.040, P=0.046), fasting blood glucose (r=0.140, P〈0.001), 2-hour post-meal blood glu-cose (r=0.121, P〈0.001), and negatively associated with HDL-C (r=-0.128, P=0.048).There was a strong association between baPWV and prevalence of MetS and its component number in females but not in males .Compared with the lowest quartile of baPWV , the adjusted ORs were 1 .22 ( 95%CI 0.83-1.79), 1.32(95%CI 0.90-1.93), 1.46(95%CI 1.00-2.14) in males and 1.28(95%CI 0.93-1.77), 1.55(95%CI 1.12 -2.16), 1.86(95%CI 1.32-2.61) in females for the second, third and top quartiles .Conclusion:The prevalence of MetS increases substantially with increasing levels of baPWV among the Chinese elderly , especially in females .