中文摘要：

食管鳞癌是我国常见的消化道恶性肿瘤,进展快且预后差。由于早期一般无明显症状,临床确诊的食管鳞癌大多已发展到了中晚期,治愈难度较大。越来越多的证据表明,在食管鳞癌发生发展过程中,染色体及基因组DNA畸变均是最常见的遗传学改变。文章就食管鳞癌染色体及基因组水平异常的研究进展作一综述。

英文摘要：

Esophageal squamous cell carcinoma（ESCC） is one of the most common malignancies with poor prognosis in China.Patients with ESCC may present with vague symptoms in early stage and most of the cases are diagnosed at advanced stage,without the chance of optimal therapy.In the development and progression of ESCC,cytogenetic and molecular aberrations are frequently observed.This review is to summarize the advances in the chromosomal and genomic alterations of ESCC reported recently.