中文摘要：

利用现代细胞生物学、分子生物学技术开展经典天然产物的分子机制研究，建立合适的体外活性评价模型系统，然后通过药物化学技术进一步研究其结构与活性、结构与毒性、结构与ADME（absorption，distribution，metabolism and excretion）性质的关系，是我国发现具有自主知识产权新药的一条有效途径。

英文摘要：

We think the strategy of classic natural product-based drug discovery will be an effective way for us to develop new drugs with independent intellectual property. The strategy includes： to study the molecular mechanism of action of classic natural product with chemical genetics and chemical biology approaches firstly; then establish the proper in vitro bioassay or bioassay system based on its molecular mechanism for their pharmacodynamic evaluation; finally, study their structure-activity, structure-toxicity and structure-ADME properties with medicinal chemistry.