中文摘要：

胃肠平滑肌层富有特殊分化的两种间质细胞,包括Cajal间质细胞（interstitial cells of Cajal,ICC）以及血小板衍生因子受体α阳性细胞（platelet-derived growth factor receptorα-positive cells,PDGFRα~＋细胞）。ICC和PDGFRα~＋细胞分别与平滑肌细胞（smooth muscle cells,SMC）形成缝隙连接调控平滑肌的收缩功能,因此,这三种细胞共同构成功能性的合胞体,称为SMC、ICC和PDGFRα＋细胞合胞体（SIP合胞体）。各种神经递质、体液因子、内源性生物活性分子以及药物等可以通过SIP合胞体影响胃肠运动。本文综述了SIP合胞体及其作用机制以及生理与病理生理学意义。

英文摘要：

Gastrointestinal smooth muscle layer contains two kinds of interstitial cells with special differentiation, i.e., interstitial cells of Cajal （ICC） and platelet-derived growth factor receptor a-positive （PDGFRct＋） cells. The ICC and PDGFRu＋ cells contact with smooth muscle cells （SMCs） by gap junctions and regulate contractive function of the SMCs. Therefore, these three kinds of cells constitute a functional syncytium, i.e., the SMC, ICC and PDGFRct＋ cells syncytium （SIP syncytium）. Various neurotransmitters, humoral factors, endogenous bioactive molecules, as well as drugs regulate gastrointestinal motility through the SIP syncytium. In this review, we introduce the concept of SIP syncytium and summarize functions of the syncytium, as well as its physiological and patho- logical significances.