中文摘要：

目的初步探讨白细胞介素-23（IL-23）的表达水平与结核病之间的关系,明确其是否参与结核免疫反应。方法计算机检索中国知网、万方数据库、维普网、PubMeb、ProQuest数据库相关文献,检索从建库到2016年12月的文献,文献按照纳入和排除标准,选择有关结核IL-23表达水平的研究性论文,并对纳入文献进行质量评价,数据处理采用RevMan5.2软件进行Meta分析。结果最终纳入研究的文献有9篇（其中1篇同时含有血清和脑脊液数据）。Meta分析结果显示结核患者血清IL-23水平明显高于正常对照者,MD=44.96,95%CI25.75～64.16（P〈0.01）;结核性脑膜炎患者脑脊液IL-23水平也高于对照组,MD=91.47,95%CI22.63～160.31（P〈0.01）。结论血清、脑脊液中IL-23水平升高与结核免疫有关。

英文摘要：

Objective To preliminarily study on the relationship between IL-23 expression levels and tu berculosis and to determine whether it is involved in tuberculosis immune response. Methods A systematic literature search of CNKI,Wanfang database, VIP database, PubMed and ProQuest from their establishment to December 2016 was performed for collecting the research studies investigating the IL-23 expression in tuberculosis patient published in China and abroad. The literatures about tuberculosis IL-23 expression were screened out according to the inclusion and exclusion criteria and the quality of included studies was evaluated. A metaanalysis was performed for the collected data from included literatures by using RevMan 5.2 software. Results Nine eligible studies were included[one of them had both serum and cerebrospinal fluid （CSF） data]. The meta-analysis results were shown that the expression level of serum IL-23 in patients with tuberculosis was higher than that in the normal control group, MD=44.96,95% CI 25.754 64.16 （ P 〈0.01）. The expression level of CSF IL-23 in patients with tuberculous meningitis was higher than that of the control group, MD= 91.47,95% CI 22. 634160.31（P 〈0.01）. Conclusion The elevation of serum and CSF IL-23 expression levels are associated with tuberculous immunity.