目的:探讨血清总胆固醇(TC)的异常改变与冠心病痰瘀证候的关系。方法:应用Meta分析法对10篇文献中冠心病"痰浊证"、"血瘀证"患者与"正常对照者"的TC含量进行综合分析。结果:TC含量显示,血瘀证患者比正常对照者标准差高0.99~2.426倍,Total合并=0.71,Total合并95%置信区间为0.16~1.25;痰浊证患者比正常对照者标准差高1.019~3.761倍,Total合并=1.05,Total合并95%置信区间为0.43~1.68。结论 :冠心病患者血瘀证和痰浊证的TC含量与正常对照者比较存在显著差异,TC含量的异常改变可作为冠心病痰瘀辨证的客观指标之一。
This study was aimed to find out the relationship between the serum total cholesterol ( TC ) and coronary heart disease ( CHD ) of phlegm and blood stasis syndrome . Meta -analysis was used on the comprehensive analysis of ten research literatures on TC content of CHD patients with "phlegm-turbid syndrome", "blood-stasis syndrome" and "normal control ." The results showed that the content of TC was 0.99-2.426 times h igher standard deviation in the blood-stasis syndrome patients than in the normal control, Totalcombined = 0.71. And the 95% confidence intervals of Totalcombined was 0.16-1.25. And the content of TC was 1.019-3.761 times higher standard deviation in the phlegm-turbid syndrome than in the normal control, Totalcombined= 1 . 05 . And the 95% confidence intervals of Totalcombined was 0 . 43-1 . 68 . It was concluded that there were significant variations of TC content in CHD patients with blood-stasis and phlegm-turbid syndrome compared to normal control . Therefore , abnormal changes of TC content can be used as one of the objective CHD diagnostic criteria of phlegm and blood stasis syndrome .