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血小板介导肿瘤血行转移的作用及其机制研究进展

ISSN号：1001-1978
期刊名称：中国药理学通报
时间：2015.1
页码：166-169
分类：R-05[医药卫生] R331.124[医药卫生—人体生理学;医药卫生—基础医学]
作者机构：[1]南京中医药大学药学院,江苏南京210023, [2]江苏省中药药效与安全性评价重点实验室,江苏南京210023
相关基金：国家自然科学基金资助项目（No81173174,81202655）;教育部博士点基金资助项目（No20113237110008）;江苏省普通高校研究生科研创新计划项目（NoKYLX_0972,KYZZ_0270）
相关项目：基于DLL4/Jagged1调控血管芽生探讨活血化瘀法在肿瘤转移中的作用

中文摘要：

肿瘤转移是恶性肿瘤最为重要的生物学特性之一，同时也是影响预后及导致治疗失败的主要因素。临床研究显示，恶性肿瘤患者的血小板数目较正常人及良性肿瘤患者明显升高，表明血小板可能参与了肿瘤的发生发展过程。进一步研究发现，血小板在肿瘤血行转移的过程中能够与肿瘤细胞相互作用形成瘤栓，逃避免疫监视，进而促进了肿瘤的转移。近年来，临床上已经开展了针对血小板治疗肿瘤转移的研究，同时，血小板促进肿瘤转移的相关作用机制也逐步地被揭示。该文对近年来血小板介导肿瘤血行转移的作用及其作用机制研究进展进行综述，探讨临床针对血小板治疗肿瘤转移的策略，为后续的科学研究及指导临床提供参考。

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期刊论文 29

基于DLL4/Jagged1调控血管芽生探讨活血化瘀法在肿瘤转移中的作用

期刊论文 98 著作 3

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