目的:本研究采用金钱奖赏范式探讨不同戒断时长(短期戒断组:平均2.7个月,中期戒断组:平均19.36个月,长期戒断组:平均49.6个月)的毒品戒断者与正常匹配组,在分辨不同额度的金钱奖赏时认知加工能力的损伤和恢复情况。方法:研究中要求被试在三种不同的奖赏条件(45分,1分,0分)下完成Go/No—go任务。结果:脑电结果表明,对不同额度的金钱奖赏加工时,短期戒断组和中期戒断组的脑区功能受损,表现为其诱发的N2和P3波幅在三种条件下差异都不显著;长期戒断组在奖赏条件下诱发的N2和P3平均波幅显著大于0分条件,但是波幅差异的程度显著低于控制组。结论:长期戒断组和控制组在神经激活模式上存在的差异,表明经过三年以上的戒断后,戒毒人员的脑功能显示出一定水平的恢复,但是仍未恢复至正常水平。
Objective: The current study aimed to explore cognitive function in drug abstainers at different healing phas- es(short-term abstinence group: average of 2.7 months, medium-term abstinence group: 19.36 per month on average, long- term abstinence group: average of 49.6 months) with a monetary reward task. Methods: This study adopted a monetary re- ward paradigm. Participants were required to complete the Go/No-go tasks in three different reward gradients(score of 45, 1, 0). Results: Eleetroencephalographic(EEG) results showed that the sensitivity to monetary reward was declined in both short- and medium-term abstinence groups who have no different brain activation on the reaction to three different reward gradients. The brain function of long-term abstinence group showed a certain level of recovery, reflected by smaller difference of P3 and N2 amplitudes to monetary reward gradient compared to the control group. Conclusion: The damage of rewards perception, assessment, and expectation caused by drug addiction earl be normalized following a long term post-drug withdrawl.