中文摘要：

β淀粉样蛋白（β-amyloid peptide,Aβ）是构成老年斑的主要成分,Aβ在阿尔茨海默病（Alzheimer’s disease,AD）的发生、发展中起主要作用。文章采用紫外和荧光光谱法研究人参皂苷Rb1与Aβ_（1-42）的相互作用,为AD药物筛选提供理论依据。研究表明,人参皂苷Rb1可以增强Aβ_（1-42）的荧光,二者发生相互作用,形成了络合物。人参皂苷Rb1与Aβ络合物的双倒数曲线呈良好的线性关系,说明人参皂苷Rb1与Aβ形成1∶1的络合物,络合常数约为214.5L·mol^-1·s^-1。

英文摘要：

β-amyloid peptide（Aβ）is the main component of senile plaque,and Aβplays a leading role in the occurrence and development of Alzheimer＇s disease（AD）.The interaction between ginsenoside Rb1 and Aβ_（1-42） was studied by UV and fluorescence spectroscopy,which could provide theoretical basis for the drug screening of AD treatment.The results showed that ginsenoside Rb1 could enhance the fluorescence of Aβ_（1-42）,and the complex was formed between ginsenoside Rb1 and Aβ.The double reciprocal plots of them showed a good linear relationship,indicating that the 1∶1complex between ginsenoside Rb1 and Aβwas formed,and the complexation constants was about 214.5L·mol^-1·s^-1.