中文摘要：

哺乳动物细胞内的甘油三酯是以脂滴的形式贮存的，现在有很多证据表明，脂滴参与多种代谢过程，因而被看作胞内有功能的细胞器。脂滴含有甘油三酯构成的脂质核心，脂核表面覆盖有单层磷脂，在单层磷脂内镶嵌着在结构上具有相关性的PAT家族蛋白，包括perilipin、ADRP、TIP47和S3—12。本文就这些蛋白在甘油三酯水解和脂滴合成中的调节作用加以综述。

英文摘要：

Triglycerides are stored in intracellular lipid droplets in mammalian cells. Current evidences suggest that the intracellular lipid droplets are active participants in a variety of metabolic processes, and thus are considered as functional organelles in cells. The lipid droplet is composed of a triglyceride core surrounded by a phospholipid monolayer in which several proteins are embedded. Four of these proteins belong to a family of structurally related PAT protein, which includes perilipin, ADRP, TIP47 and S3- 12. In this review, we summarize the functions of these proteins in the modulation of lipolysis and lipid droplets formation.