中文摘要：

探讨湖南地区汉族人群维生素D受体（VDR）基因FokⅠ位点多态性与2型糖尿病（T2DM）的关系。研究对象为853例，其中T2DM组473例和正常对照组380例。采用聚合酶链反应-限制性片断长度多态（PCR—RFLP）法检测VDR基因FokⅠ位点基因型。比较两组VDR基因FokⅠ位点基因型分布和等位基因频率，分析VDR基因FokⅠ位点多态性与胰岛β细胞功能的关系。T2DM组f等位基因频率高于正常对照组（P〈0．05），T2DM组Ff和ff基因型分布频率高于正常对照组（P〈0．05）。T2DM组FBG、PBG水平高于正常对照组（P〈0．05）。T2DM组ff基因型组的口服葡萄糖耐量后2h胰岛素低于FF基因型组（P〈0．05）。VDR基因FokⅠ多态性与中国湖南地区汉族人群T2DM发病相关，VDR基因ff基因型和Ff基因型可能是T2DM的发病风险因素。

英文摘要：

To study the association between the VDR gene Fok Ⅰ polymorphism and type 2 diabetes853 individuals were examined ：473 type 2 diabetic patients and 380 unrelated healthy subjects. The study groups were recruited from Han Chinese in Hunan province. Genotyping for VDR gene Fok Ⅰ polymorphism were performed by RFLPPCR technique. Significantly higher frequency of ff and Ff genotype and f allele was presnet in type 2 diabetic patients than in controls （ P 〈 0.05 ）. Higher levels of FBG and PBG in T2DM than controls was observed （ P 〈 0. 05 ）. T2DM patients showed lower insulin level at 2h after 75 - g oral glucose than controls （ P 〈 0.05）. VDR gene Fok Ⅰ polymorphism was associated with T2DM in Han Chinese Populations of Hunan province, suggesting VDR gene Fok Ⅰ ff genotype and Ff genotype may be a genetic mark for predicting risk of type 2 diabetes.