中文摘要：

以芝麻酚和取代吲哚醌（2a～2i）为原料,二氯甲烷为溶剂,在1,4-二氮杂二环[2,2,2]辛烷催化下经缩合反应合成了9个新型的芝麻酚与3-羟基氧化吲哚的拼接衍生物（3a～3i）,其结构经1H NMR,13C NMR和HR-ESI-MS表征.采用MTT法和SRB法研究了3a ～3i体外对人白血病细胞（K562）和人肺癌细胞（K549）的抑制活性.结果表明：5-氟-3-羟基-3-{6-羟基苯并[1,3]二氧亚甲基-5-基}-1-甲基氧化吲哚（3c）和5-氟-3-羟基-3-{6-羟基苯并[1,3]二氧亚甲基-5-基}-氧化吲哚（3g）具有较好的抗K562和K549活性.

英文摘要：

Nine novel sesamol ring-fused 3-hydroxyoxindoles（3a ～ 3i） were synthesized by condensation reaction of sesamol with substituted isatins（2a ～ 2i） using DABCO as the catalyst and CH2Cl2 as the solvent.The structures were characterized by 1H NMR,13C NMR and HR-ESI-MS.The in vitro anti-tumor activites of 3a ～ 3i against K562 and K549 were investigated by MTT method and SRB method.The results showed that 5-fluoro-3-hydroxy-3-{ 6-hydroxybenzo [d] [1,3] dioxol-5-yl }-1-methylindolin-2-one （3c） and 5-fluoro-3-hydroxy-3-{ 6-hydroxybenzo [d] [1,3] dioxol-5-yl } indolin-2-one（3g） exhibited better antitumor activities.