中文摘要：

黄酮糖苷类天然产物是植物中黄酮类化合物的主要存在形式，通过糖基化修饰，可以改变其水溶性、稳定性等，赋予其新的生物活性和功能。黄酮类化合物的糖基化修饰通常由植物源或微生物源的糖基转移酶催化，根据糖基的位置、类型和数量的不同，可形成多种类型的黄酮糖苷类产物。随着合成生物学和代谢工程的快速发展，在微生物中合成植物源黄酮糖苷类天然产物取得了重要进展。综述了糖基转移酶的聚类分析及糖基供体的途径改造，并对代谢工程优化黄酮糖苷类天然产物的微生物合成进行了分析讨论，并对其发展前景进行了展望。

英文摘要：

Flavonoid glycosides are a large group of plant-based phenolic nature products. The glycosylation of flavonoids increases their solubility and stability relative to flavonoid aglycones, mainly catalyzed by glycosyltransferases （Gts）. Uridine diphosphate glycosyhransferases play a key role in decorating flavonoids with different sugars, resulting in numerous structurally diverse flavonoid glycosides. With the rapid development of synthetic biology and metabolic engineering, engineered yeast, Escherichia coli and other microorganisms have been utilized to construct the biosynthesis pathways of sugar donors and flavonoid aglycones. The recent progress on glycosylated flavonoids in engineered microorganisms, as well as the clustering of glycosyltransferase, biosynthetic pathway of sugar donors were summarized, and its future trend was explored.