中文摘要：

目的：研究中医补肾活血法指导下中药复方（益智健脑方浓缩液）以及针刺（“补肾活血针刺法”）对阿尔茨海默病模型小鼠SAMP8（Senescence Accelerated MouseP8，SAMPS）的行为学影响，从不同侧面阐明补肾活血法对SAMP8小鼠的治疗作用以及防治AD的可行性。方法：将5月龄雄性SAMP830只随机分为中药治疗组（n=10）、针刺治疗组（n=10）和模型对照组（n=10），中药治疗组以益智健脑方浓缩液灌胃；针刺治疗组予以“补肾活血针刺法”干预；模型对照组不予任何处理；另设5月龄雄性SAMR1小鼠（n=10）作为正常对照组。4周后，采用Morris水迷宫对各组小鼠的行为学进行检测分析其学习记忆能力的变化。结果：Morris水迷宫实验中，模型对照组SAMP8小鼠的逃避潜伏期较正常对照组SAMR1小鼠的逃避潜伏期时间明显延长（P〈0．05），停留在原平台象限的时间和穿越原平台次数较正常对照组SAMR1小鼠明显减少（P〈0．05）；补肾活血法指导下，采用中药复方益智健脑方浓缩液以及“补肾活血针刺法”干预均能够明显缩短SAMP8小鼠的逃避潜伏期（P〈0．05），增加其停留在原平台象限的时间和穿越原平台次数（P〈0．05）。结论：补肾活血法能够明显改善AD模型小鼠SAMP8的学习记忆能力以及记忆巩固、再现能力。

英文摘要：

Objective： To explore the effect of a chinese herbal compound （the Concentrated Fluid of YiZhiJianNao Decoction, CFYD） and acupuncture （Kidney-reinforcing and Blood-activating Acupuncture Method, KBAM）, both under the guideline of Kidney-reinforcing and Blood-acti vating therapy method, on the behavior of senescence-accelerated mice P8 （SAMP8） which is considered as an generally accepted mouse model of Alzheimer＇s disease, thus to elucidate the therapeutic effect of Kidney-reinforcing and Blood-activating therapy on SAMP8. Methods： 30 five-month-old male SAMP8 were randomly divided into three groups： chinese herbal treatment group（n=10）, acupuncture treatment group（n=10） and model control group （n =10）. Another 10 five-month-old male SAMR1 mice were prepared as normal control group （n-10）. Mice in chinese herbal treatment group were treated with intragastric administration of CFYD, Mice in acupuncture treatment group were intervened by KBAM, while mice in model control group and normal control group were raised without special treatment. After 4 weeks, using Morris water maze for mice in each group to analyze its behavior to detect changes in learning and memory ability. Results： In Morris water maze test, SAMP8 mice in the model control group had longer escape latency compared with SAMR1 mice in normal control group （p〈0.05）; For SAMP8 mice in the model control group, the stay time in the former platform quadrant and former platform crossing times were much less than SAMR1 mice in normal control group （p〈0.05）; With the intervention of Kidney-reinforcing and Blood-acti vating therapy, for CFYD and KBAM, both of them can significantly shorten the escape latency and increase the stay time in the former platform quadrant and former platform crossing times of SAMP8 mice （p〈0.05）. Conclusions： The intervention of Kidney-reinforceing and Blood-activating therapy（represented by CFYD and KBAM） in traditional chinese medicine can significantly improve the lear