Organocatalytic Asymmetric Double Michael Reaction of Benzofuranone with Dienones to Construct Spirocyclic Benzofuranones
- ISSN号:1001-604X
- 期刊名称:《中国化学:英文版》
- 时间:0
- 分类:TQ314.249[化学工程—高聚物工业] O621.256.7[理学—有机化学;理学—化学]
- 作者机构:[1]Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, Sichuan 610041, China, [2]Graduate University of Chinese Academy of Sciences, Beijing 10039, China
- 相关基金:Acknowledgement This work was supported by National Natural Science Foundation of China (Nos. 20802075 and No. 21042006).
作者:
罗西娅[1,2], 汪亮完[1,2], 彭林[1], 摆建飞[1,2], 贾利娜[1,2], 田芳[1], 徐小英[1], 王立新[1]
关键词:
MICHAEL加成反应, 苯并呋喃酮, 有机催化, 螺环, 不对称, 对映选择性, 光学活性, 伯胺, double Michael reaction, spirocyclic compounds, benzofuranone, organocatalysis
中文摘要:
有 dienones 的 benzofuranone 的两倍迈克尔反应由基于辛可宁的主要的胺催化的 enantioselective 被开发。很多光学地活跃的 spirocyclic benzofuranones 在多达 89% 产量和 91% ee 被获得。
英文摘要:
The enantioselective double Michael reaction of benzofuranone with dienones catalyzed by Cinchona-based primary amines was developed. A number of optically active spirocyclic benzofuranones were obtained in up to 89% yield and 91% ee.