中文摘要：

目的模拟生理调节状态下随着眼调节和瞳孔直径的变化人眼高阶像差的波动特点。设计前瞻性比较性研究。研究对象21例正常人眼与模拟眼。方法通过控制视路上移动视标的位置诱发人眼调节,在调节过程中,不人为控制瞳孔直径,使其处于自然收缩舒张状态,实时用哈特曼波前传感器（Hartman-Shark）采集人眼波前像差。模拟眼作为对照。主要指标人眼与模拟眼的总波前像差的均方根（t-RMS）和高阶像差的均方根（h-RMS）及其变异系数。结果生理调节状态下,人眼的t-RMS为（0.46±0.18）μm;h-RMS为（0.27±0.14）μm,变异系数分别为40.37%和36.34%;模拟眼的t-RMS为（0.39±0.00）μm,变异系数为0.47%。人眼高阶像差与瞳孔直径和调节屈光度线性相关,回归方程为：h-RMS=0.111×瞳孔直径（mm）-0.015×离焦屈光度（D）-0.313（P〈0.001,R2=0.458）。结论人眼波前像差在生理调节状态下具有显著波动。瞳孔直径是主要的影响因素。

英文摘要：

Objective To investigate the dynamic characteristics of ocular wavefront aberrations and discuss the relationship between aberrations and pupil size,as well as the relationships between aberrations and accommodation under simulated physiological conditions.Design Prospective comperative study.Participants Normal eyes（21 cases） and the simulated eye.Methods The condition of ocular accommodation was controlled by the moving visual target when the value of the wavefront aberrations was collected by Hartmann-Shark aberrometry.The simulated eye was used as the control.Main Outcome Measures The root mean square of total wavefront aberration（t-RMS） and high-order aberration（h-RMS） from normal eyes and the simulated eye and their coefficient of variance.Results In normal eye,the mean t-RMS was 0.46±0.18 μm;the mean h-RMS was 0.27±0.14 μm,the coefficient of variance was 40.37% and 36.34%,respectively.As a control,the mean t-RMS and coefficient of variance of the simulated eye＇s was 0.39±0.00 μm and 0.47% respectively.The h-RMS of normal eyes was correlated with pupil sizes and accommodation.The regression equation could be expressed as： h-RMS= 0.111 × pupil diameter（mm）-0.015 × dioptre（D）-0.313（P0.001,R2=0.458）.Conclusion The ocular wavefront aberrations could change significantly under physiological conditions.The pupil size is the main factor.