中文摘要：

目的：评价双金康药烟的脱毒药效学。方法：采用剂量递增法建立吗啡依赖大鼠催促戒断模型、吗啡依赖大鼠自然戒断模型以及吗啡依赖猴自然戒断模型，然后给予双金康药烟进行治疗。结果：双金康药烟1．6、3．2g·kg^-1 2个剂量均可显著降低吗啡依赖大鼠催促戒断症状的分值（P〈0．01），抑制体质量明显下降（P〈0．05或0．01）；双金康药烟1．6、3．2g·kg^-1 2个剂量还能控制吗啡依赖大鼠自然戒断症状的分值（P〈0．05或0．01），抑制体质量明显下降（P〈0．05或0．01）；双金康药烟0．7、1．4、2．8g·kg^-1 3个剂量均能在不同程度上控制吗啡依赖猴自然戒断的戒断症状，减轻体质量下降（P〈0．05或0．01）。结论：双金康药烟可减轻吗啡依赖动物的戒断反应。

英文摘要：

OBJECTIVE To evaluate the detoxification effect of Shuangjinkang（SJK） smoke agent. METHODS Models of morphine-dependent rats and monkeys were established by dose-increasing administration. After precipitated by naloxone or natural withdrawal,the abstinent syndromes and weight loss of addictive rats and monkeys were observed. RESULTS SJK 1.6,3. 2 g·kg^-1 significantly decreased the score of withdrawal syndromes （P〈0.01） and controlled the weight loss （P〈0. 05 or 0. 01 ） in the rat models of natural withdrawal test. SJK smoke agent had also the same effect in the rat models of withdrawal test. SJK smoke agent 0. 7,1.4,2. 8 g·kg^-1 controlled the withdrawal syndromes and inhibited the weight loss in monkeys （P〈 0. 05 or 0. 01）. CONCLUSION Shuangiinkang smoke agent showed a significant detoxification effect on models of morphinedependent rats and monkeys.