中文摘要：

乙型肝炎预防性疫苗成功地降低了HBV的感染率，但是HBV感染仍然是全球性的健康问题。目前针对HBV感染导致的慢性乙型肝炎尚无完全有效的治疗方法。慢性乙型肝炎的免疫治疗是近年来的研究热点，尤其治疗性疫苗更是一种很有前景的治疗策略。慢性乙型肝炎治疗性疫苗目的在于诱导HBV特异性的免疫应答，打破免疫耐受，最终清除HBV。随着对HBV感染后临床转归机制研究的进一步透彻，慢性乙型肝炎免疫治疗的研究也取得显著进展。

英文摘要：

Although prophylactic HBV vaccine has reduced the incidence, hepatitis B is still a world- wide health problem. Till now, there is no perfect treatment for chronic hepatitis B caused by HBV infection. Nowadays, Immune based therapies of chronic hepatitis B, especially therapeutic vaccine, become a research hotspot as promising new strategy. Therapeutic vaccine aims to induce HBV specific immune response, to break immune tolerance and eventually to clear the HBV. Immune based therapy research has made significant progress. Moreover, new insight has been abtained by the researches on the mechanism of the clinical outcomes after HBV infection.