中文摘要：

采用乙醇-水混合溶液为溶剂,以NaOH为沉淀剂制备了甲氨蝶呤（MTX）-镁铝层状双氢氧化物（Mg-Al-LDH）纳米复合材料,利用X-射线衍射（XRD）、透射电镜（TEM）和傅里叶变换红外（FT-IR）光谱等表征手段,对其结构及形貌进行了系统研究.研究表明,与传统的水溶液共沉淀法相比,醇水共沉淀法制备的MTX/LDH纳米复合物为球形片状,粒径较小,且分散性好.研究了醇水体积比对MTX/LDH纳米复合物性质的影响,结果表明,MTX分子以单层倾斜方式插入氢氧化物层间,随着合成条件的变化倾斜角度发生改变.当醇水体积比为1∶3时,制得的粒子最小,且大小均匀,无团聚现象.在磷酸缓冲液中考察了不同粒径MTX/LDH纳米复合物的缓释性能,结果表明,粒径小的MTX/LDH纳米粒子缓释效果优于粒径大的.

英文摘要：

The methotrexatum（MTX） was intercalated into the layered double hydroxides（LDHs） to form the MTX/LDH compounds,by the coprecipitation method in the alcohol-water mixed solvent（alcohol-water co-precipitation for short） and NaOH as precipitator.The influence of alcohol-water solvent on the structure of MTX/LDH compounds was systematically investigated by X-ray diffraction（XRD）,transmission elec-tron micrograph（TEM）,fourier transform infrared spectroscopy（FTIR） and differential thermal analysis（DTA） techniques.The studies indicated that compared with the conventional coprecipitation method in wa-ter solvent,the morphology of the particles prepared by the alcohol-water coprecipitation was spherical shape with smaller size and had a good dispersion.MTX anions were intercalated into the LDH sheets as a delined monolayer and the declined angles changed with the variation of the volume ratio of ethanol to wa-ter.Our results showed that when the volume ratio of alcohol to water was 1∶3,the particles are the small-est and uniform without agglomeration.At last,the drug release rates with different particles＇ size were studied in phosphate buffer and it showed that the smaller MTX/LDH nanoparticles have the longer release time than those of the larger ones.