中文摘要：

格格声结构由于唯一的 core@void@shell 体系结构和函数的集成是对 nanomaterials 的设计和申请的大兴趣的一个话题。此处，我们开发了一个新奇 ship-in-a-bottle 方法制作 upconverting (UC ) 由把做 lanthanide 的氟化物合并到空 mesoporous 的光 nanorattles 硅石。nanorattles 的尺寸和氟化物的充满的数量能很好被控制。另外，硅石壳的修正(与苯撑和胺组) 并且有效 UC 氟化物的变化(NaYF ₄:Yb,Er, NaLuF ₄:Yb,Er, NaGdF ₄:Yb,Er 和 LiYF ₄:Yb,Er) 乐意地被完成。产生 nanorattles 展出了一个高能力和反癌症药 doxorubicin (纪录影片) 的 pH 依赖的版本。而且，我们由从 UC 氟化物利用精力转移过程到纪录影片在 proof-of-concept 监视 UC 药版本采用了这些 nanorattles，因此作为有效癌症 theranostic 揭示 nanorattles 的大潜力代理人。

英文摘要：

Rattle structure is a topic of great interest in design and application of nano- materials due to the unique core@void@shell architecture and the integration of functions. Herein, we developed a novel ＂ship-in-a-bottle＂ method to fabricate upconverting （UC） luminescent nanorattles by incorporating lanthanide-doped fluorides into hollow mesoporous silica. The size of nanorattles and the filling amount of fluorides can be well controlled. In addition, the modification of silica shell （with phenylene and amine groups） and the variation of efficient UC fluorides （NaYF4：Yb, Er, NaLuF4：Yb, Er, NaGdF4：Yb, Er and LiYF4：Yb, Er） were readily achieved. The resulting nanorattles exhibited a high capacity and pH-dependent release of the anti-cancer drug doxorubicin （DOX）. Furthermore, we employed these nanorattles in proof-of-concept UC-monitoring drug release by utilizing the energy transfer process from UC fluorides to DOX, thus revealing the great potential of the nanorattles as efficient cancer theranostic agent.