中文摘要：

目的：研究VSD负压引流技术结合游离植皮治疗大面积皮肤缺损临床疗效。方法：选择2012年4月至2013年10月入我院接受治疗的大面积皮肤缺损患者65例，将其随机分为观察组（35例）与对照组（30例）。观察组患者术前先采用VSD治疗，游离植皮术后继续给予VSD治疗；对照组患者采取打压植皮或传统打包加压治疗。观察和比较两组患者的皮片成活时间、皮片成活率、术后住院治疗时间、换药次数、疼痛评分及家属满意度。结果：观察组患者的皮片成活时间短于对照组、皮片成活率高于对照组、住院时间短于对照组，换药次数少于对照组，两组之间的差异具有统计学意义（P〈0．05）。此外，观察组患者的疼痛视觉模拟评分明显低于对照组，患者家属的满意度评分明显高于对照组，差异具有统计学意义（P〈0．05）。结论：相对于传统的打压植皮或传统打包加压的技术而言，VSD负压引流技术结合游离植皮在治疗大面积皮肤缺损的临床疗效更好，值得在临床上推广使用。

英文摘要：

Objective： To study the clinical efficacy of VSD negative pressure drainage technology combined with free skin graft in the treatment of large area skin defect of clinical curative effect. Methods： 65 patients with large area skin defects admitted in our hospital from April 2012 to October 2013 were chosen and randomly divided into the observation group （35 cases） and control group （30 cases）. Patients of observation group were treated by VSD before surgery and after free skin grafting. Patients of control group were treated by traditional suppression of skin graft or traditional pressurized packaging technology. The skin graft survival time, skin graft survival, hospital days, switching frequency, pain score and family satisfaction were observed and compared between two groups. Results： Compared with the control group, the skin graft survival time of observation group was shorter, the flap survival rate was higher, the length of time was shorter, the switching frequency was less, the pain score of observation group was significantly lower, the family satisfaction was higher, the differences between the two groups had statistical significance （P〈0.05）. Conclusion： Compared with the traditional suppression of skin graft or traditional pressurized packaging technology, the VSD negative pressure drainage technology combined with free skin graft was more effective in the treatment of large area skin defects, which was worth popularizing in clinical use.