中文摘要：

探讨羟基磷灰石（HAP）纳米粒子负载阿霉素后的体外抗肿瘤活性。通过纳米粒子与人肝癌Bel-7402细胞和人正常肝细胞L02的体外培养，研究阿霉素负载HAP纳米粒子的心肌毒性，以及对肿瘤细胞凋亡的影响。MIT（四甲基偶氮唑蓝盐）法检测表明，阿霉素负载HAP纳米粒子对Bel-7402细胞的抑制率为95．22％，明显高于HAP纳米粒子（16．26％）和阿霉素（83．36％）（P〈0.05）。倒置相差显微镜观察显示，阿霉素负载HAP纳米粒子比单用阿霉素有更大的肿瘤抑制效应，并降低心肌毒性。

英文摘要：

The aim of this paper was to study the anti-tumor activity in vitro of adriamycin-loaded hydroxyapatite （HAP） nanoparticles. The cardiac toxicity of adriamycin-loaded HAP nanoparticles was studied by the in vitro cell cultures. MTT （ Blue methyl thiazolyl tetrazolium salt） assay showed that the inhibition rate of adriamycin-loaded HAP nanoparticles was 95.22%, which was significantly higher than HAP nanoparticles （16.26%） and adriamycin （83.36%） （ P 〈 0.05）. Inverted microscope observations also showed that the inhibition effect of adriamycin-loaded HAP nanoparticles on cancer cells was better than that of anti-tumor and the cardiac toxicity of adriamycin was reduced as well.