中文摘要：

以万古霉素和1,6-己二异腈酸酯为单体,通过界面聚合法在聚砜基膜上制备了万古霉素手性高分子膜.利用红外光谱及扫描电子显微镜对该膜进行了表征.将其用于青霉素及头孢菌素类药物的重要中间体苯甘氨酸的手性拆分,通过优化单体摩尔比、界面聚合时间及外消旋体溶液浓度等分离参数,可达到超过70%的D-苯甘氨酸对映体过剩值的手性分离.通过比较研究手性膜吸附、固相萃取、膜色谱、膜渗析和膜超滤过程,发现手性膜上优先吸附的对映体L-苯甘氨酸并不是各种模式下优先透过的对映体,结合外消旋体的缔合特性,提出了＂吸附-缔合-扩散＂的手性膜分离机理.

英文摘要：

Using vancomycin and 1,6-diisocyanatohexane as the monomers,an enantioselective composite membrane was prepared by interfacial polymerization on a polysulfone support and was analyzed by Fourier transform infrared spectroscopy and scanning electron microscopy. The composite membrane was used for enantioseparation of D,L-phenylglycine which is an indispensable reagent in the syntheses of penicillins and cephalosporins. By optimizing the molar ratio of vancomycin and 1,6-diisocyanatohexane,the time of polymerization and the feed concentration of the racemate,an enantiomeric excess[e. e.（ %） ] of over 70% D-phenylglycine could be obtained. Comparing the membrane adsorption,solid extraction,membrane chromatography,dialysis and ultrafiltration of vancomycin optical resolution membrane,the L-phenylglycine was prior adsorbed,while,the D-phenylglycine was first permeated the membrane. Based on the association characteristic of racemate of D,L-phenylglycine,we suggested,in the first time,that the enantioseparation mechanism of membrane was＂adsorption-association-diffusion＂.